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Imaging mass spectrometry device Product List

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[Analysis Case] Component Analysis of Hair Roots

[Analysis Case] Component Analysis of Hair Roots

Visualization of biological components such as cholesterol and fatty acids using TOF-SIMS.

The hair roots of human hair (both shed hair and pulled hair) were pressed against a Si wafer, and imaging measurements (surface analysis) were conducted on the transferred components. Shed hair shows a strong tendency for ■K and ●phospholipids to be present only at the tip of the hair root. Additionally, it is believed that the entire hair root contains ■CnHmCOOH (n=17–31) fatty acids (derived from human sebum), ●amide components derived from keratin plugs, ◆nitrogen-containing organic acids with a mass of 500–700, and ◆organic substances with a mass around 800 that are aggregated. However, the organic substances containing two COOH groups derived from human sebum, which are observed in pulled hair, show a weak tendency.

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  • Imaging mass spectrometry device

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[Analysis Case] Evaluation of Composition Distribution in Bone Cross-Sections

[Analysis Case] Evaluation of Composition Distribution in Bone Cross-Sections

Visualization of the composition distribution of mouse tibial cross-sections using TOF-SIMS.

To evaluate the component distribution in mouse tibia, we prepared tibial sections and conducted imaging analysis using TOF-SIMS. The distribution of components derived from mice, such as K, Ca, calcium phosphate, and phospholipids, was confirmed. Since TOF-SIMS identifies components based on the mass of molecular ions, it does not require labeling substances like fluorescent materials, allowing for distribution evaluation without the influence of labeling agents. This technique can be applied to drug dynamics analysis and research on Drug Delivery Systems (DDS), enabling imaging of drug distribution within organs.

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  • Imaging mass spectrometry device

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[Analysis Case] Component Analysis of Water Repellent Areas

[Analysis Case] Component Analysis of Water Repellent Areas

TOF-SIMS enables wide-area imaging evaluation of multiple components.

To investigate the causes of defects such as poor adhesion, it is important to gain insights into the surfaces of wafers and devices. In this instance, hydrophobic areas were observed on a silicon wafer, prompting wide-area imaging using TOF-SIMS. As a result, components estimated to be silicone oil, CF-based grease, and paraffin oil were identified from the hydrophobic areas. TOF-SIMS typically has a measurement field of view up to 500μm square, but by moving the stage during measurement, it is possible to evaluate wide-area distributions. Measurement method: TOF-SIMS Product fields: Devices, Displays, Electronic Components, Manufacturing Equipment Analysis objectives: Qualitative, Imaging, Composition Distribution Evaluation For more details, please download the materials or contact us.

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  • Contract measurement
  • Imaging mass spectrometry device

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rapifleX MALDI TOF（/TOF)

rapifleX MALDI TOF（/TOF)

rapifleX will revolutionize the common understanding of MALDI imaging measurements.

**Features** - Rapid analysis at 50 pixels/second with clear images - Improved pixel reproducibility with 10kHz smartbeamTM 3D - Spatial resolution with pixel size <5μm enables more advanced information exploration - Durability significantly enhanced by a newly designed ion source - Wide dynamic range achieved with a 10-bit digitizer - MS/MS mass range up to 8 kDa - 3-stage gridless design: uncompromising maximum resolution across the entire molecular weight range

  • Analytical Equipment and Devices
  • Imaging mass spectrometry device

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